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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
S1PR1
All Species:
27.27
Human Site:
S251
Identified Species:
60
UniProt:
P21453
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P21453
NP_001391.2
382
42811
S251
A
S
R
S
S
E
K
S
L
A
L
L
K
T
V
Chimpanzee
Pan troglodytes
XP_513598
382
42768
S251
A
S
R
S
S
E
K
S
L
A
L
L
K
T
V
Rhesus Macaque
Macaca mulatta
XP_001107778
331
36908
V209
Y
I
L
F
C
T
T
V
F
T
L
V
F
I
A
Dog
Lupus familis
XP_547259
382
42503
S251
A
S
R
S
S
E
K
S
L
A
L
L
K
T
V
Cat
Felis silvestris
Mouse
Mus musculus
O08530
382
42595
S251
A
S
R
S
S
E
K
S
L
A
L
L
K
T
V
Rat
Rattus norvegicus
P48303
383
42727
S252
A
S
R
S
S
E
K
S
L
A
L
L
K
T
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001520197
378
41947
S247
A
S
R
S
S
E
K
S
L
A
L
L
K
T
V
Chicken
Gallus gallus
XP_422305
379
42371
S248
A
T
R
S
S
E
K
S
L
A
L
L
K
T
V
Frog
Xenopus laevis
Q9PU17
366
41345
H244
K
T
M
R
M
S
R
H
S
S
G
P
R
R
N
Zebra Danio
Brachydanio rerio
Q9DDK4
362
40583
I240
M
A
L
L
K
T
V
I
I
V
L
S
C
F
I
Tiger Blowfish
Takifugu rubipres
Q9PUQ8
384
42694
W247
V
G
V
F
I
A
C
W
M
P
I
F
V
L
L
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
85
95
N.A.
93.9
93.2
N.A.
85.8
84.2
36.6
68
48.9
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
99.7
85.5
97.6
N.A.
96.8
96.3
N.A.
89.5
90.3
59.6
80.3
69.7
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
6.6
100
N.A.
100
100
N.A.
100
93.3
0
6.6
0
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
13.3
100
N.A.
100
100
N.A.
100
100
26.6
26.6
20
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
64
10
0
0
0
10
0
0
0
64
0
0
0
0
10
% A
% Cys:
0
0
0
0
10
0
10
0
0
0
0
0
10
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
64
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
19
0
0
0
0
10
0
0
10
10
10
0
% F
% Gly:
0
10
0
0
0
0
0
0
0
0
10
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
10
0
0
0
0
0
0
0
% H
% Ile:
0
10
0
0
10
0
0
10
10
0
10
0
0
10
10
% I
% Lys:
10
0
0
0
10
0
64
0
0
0
0
0
64
0
0
% K
% Leu:
0
0
19
10
0
0
0
0
64
0
82
64
0
10
10
% L
% Met:
10
0
10
0
10
0
0
0
10
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% N
% Pro:
0
0
0
0
0
0
0
0
0
10
0
10
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
64
10
0
0
10
0
0
0
0
0
10
10
0
% R
% Ser:
0
55
0
64
64
10
0
64
10
10
0
10
0
0
0
% S
% Thr:
0
19
0
0
0
19
10
0
0
10
0
0
0
64
0
% T
% Val:
10
0
10
0
0
0
10
10
0
10
0
10
10
0
64
% V
% Trp:
0
0
0
0
0
0
0
10
0
0
0
0
0
0
0
% W
% Tyr:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _